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Premarin is a prescription medication that consists of conjugated estrogens. It has been on the market since 1942 when it was approved for use as a form of hormone replacement therapy. It is most often used in post menopausal women who are experiencing hot flashing, itching, burning, and dryness of the vagina. It is commonly used in women who have had a hysterectomy, although it can be used in women who have not had the procedure that removes the uterus and often the fallopian tubes and at least one ovary. While most commonly used as hormone replacement therapy, Premarin is often prescribed off label to treat osteoporosis.

Premarin is available in several different dosages, allowing doctors to find the dosage that will best help each woman control her symptoms. There are oral tablets including the dosages of.3mg, .45mg, .9mg, and 1.25mg. It is also a medication that is available intravenously and even in a topical form.

Like all medications on the market, past and present, Premarin can cause some unintended side effects. These side effects may range from mild to severe, with some patients not experiencing any side effects at all. Possible side effects include vaginal yeast infections, vaginal spotting, bleeding, painful menses, and leg cramps. There is also some data that would suggest that there is an increased risk of coronary heart disease and breast cancer. This data is associated with studies that have found that estrogen and progestin replacements may also cause breast cancer. Premarin should be used in the smallest dose possible for the shortest period of time because it also is known to increase the risk of endometrial cancer, stroke, blood clots, and dementia.